My dual exhaust runs through exhaust manifolds, 2 1/2 pipe, and flowmaster 50 series (three chamber). It is loud enough to set off car alarms when I drive by, and it is about as loud as is acceptable for long drives. My buddy had headers that flowed into flowmaster 40 series (two chamber) and the heat from the headers and the loudness of the pipes made the truck uncomfortable to drive and difficult to talk to one another in the cab. He ended up removing the headers and putting on manifolds. He didn't notice a loss in power.
Unlike the others in this thread, I don't recommend headers unless you build an engine that can take advantage of the benefits they provide. As Robert said, you'll lose on the bottom and they'll only help you on the top end, so unless you run the truck at high rpm's (I.e. Rebuild a high performance engine with a cam), your wasting your money on headers.